Congratulations to Mick and all others who worked hard on this story, unraveling the immune cells driving toxicity (colitis) in patients treated with immune checkpoint inhibition. We show that activated, proliferating Tissue-resident memory CD8+ T cells are causing trouble in the colon.
Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor colitis
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Paper alert: T cell location in the tumor matters for dMMR colon cancer metastasis
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