Paper alert: T cell location in the tumor matters for dMMR colon cancer metastasis

Congratulations to Emre and Matthijs for the successful finish of their collaborative project manuscript!  A fantastic collaborative effort between the Kranenburg & Vercoulen labs with our outstanding clinical team with experts in oncology & pathology. We identified a potential spatial biomarker in primary tumor for metastasis of MSI-hi/MMRd colorectal cancer. We will follow this up in extended cohorts in new research projects,  funded by Sacha Swarttouw Hijmans Stichting. Here you can find the preprint, and the publication will come out soon @ British Journal of Cancer.                                                                                                                                                                                          Preprint: Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer                                                                                                                                                        BioRxiv 2023, DOI: 10.1101/2023.10.09.561039                                                                                                  

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In our memories: Neeraj Sinha

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Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor colitis